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Uncovering universal rules governing the selectivity of the archetypal DNA glycosylase TDG
Thymine DNA glycosylase (TDG) is a pivotal enzyme with dual roles in both genome maintenance and epigenetic regulation. TDG is involved in cytosine demethylation at CpG sites in DNA. Here we have used molecular modeling to delineate the lesion search and DNA base interrogation mechanisms of TDG. Fir...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003370/ https://ncbi.nlm.nih.gov/pubmed/29784784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803323115 |
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