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Secondary Interaction Interfaces with PCNA Control Conformational Switching of DNA Polymerase PolB from Polymerization to Editing
Replicative DNA polymerases (Pols) frequently possess two distinct DNA processing activities – DNA synthesis (polymerization) and proofreading (3′–5′ exonuclease activity). The polymerase and exonuclease reactions are performed alternately and are spatially separated in different protein domains. Th...
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| Publicado no: | J Phys Chem B |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5001886/ https://ncbi.nlm.nih.gov/pubmed/27109703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b02082 |
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