Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

MTOR (mechanistic target of rapamycin) is a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation. Here we show that conditional knockout (cKO) of Mtor in either primordial or growing oocytes caused infertility but differentially affecte...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Guo, Jing, Zhang, Teng, Guo, Yueshuai, Sun, Tao, Li, Hui, Zhang, Xiaoyun, Yin, Hong, Cao, Guangyi, Yin, Yaoxue, Wang, Hao, Shi, Lanying, Guo, Xuejiang, Sha, Jiahao, Eppig, John J., Su, You-Qiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003357/
https://ncbi.nlm.nih.gov/pubmed/29784807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800352115
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