Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

MTOR (mechanistic target of rapamycin) is a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation. Here we show that conditional knockout (cKO) of Mtor in either primordial or growing oocytes caused infertility but differentially affecte...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Guo, Jing, Zhang, Teng, Guo, Yueshuai, Sun, Tao, Li, Hui, Zhang, Xiaoyun, Yin, Hong, Cao, Guangyi, Yin, Yaoxue, Wang, Hao, Shi, Lanying, Guo, Xuejiang, Sha, Jiahao, Eppig, John J., Su, You-Qiang
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003357/
https://ncbi.nlm.nih.gov/pubmed/29784807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800352115
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