Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

MTOR (mechanistic target of rapamycin) is a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation. Here we show that conditional knockout (cKO) of Mtor in either primordial or growing oocytes caused infertility but differentially affecte...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Guo, Jing, Zhang, Teng, Guo, Yueshuai, Sun, Tao, Li, Hui, Zhang, Xiaoyun, Yin, Hong, Cao, Guangyi, Yin, Yaoxue, Wang, Hao, Shi, Lanying, Guo, Xuejiang, Sha, Jiahao, Eppig, John J., Su, You-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003357/
https://ncbi.nlm.nih.gov/pubmed/29784807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800352115
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