Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma

Glioblastoma (GBM) remains incurable, and recurrent tumors that rarely respond to standard-of-care radiation and chemo therapies. Therefore, strategies that enhance the effects of these therapies should provide significant benefits to GBM patients. We have developed a nanoparticle delivery vehicle t...

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Detalhes bibliográficos
Publicado no:Nanomedicine
Main Authors: Kievit, Forrest M., Wang, Kui, Ozawa, Tatsuya, Tarudji, Aria W., Silber, John R., Holland, Eric C., Ellenbogen, Richard G., Zhang, Miqin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002851/
https://ncbi.nlm.nih.gov/pubmed/28614736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2017.06.004
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