Antimicrobial sulfonamides clear latent Kaposi Sarcoma Herpesvirus infection and impair MDM2-p53 complex formation

Kaposi Sarcoma Herpesvirus (KSHV), also known as Human Herpesvirus 8, is the causative agent of Kaposi sarcoma; this malignant angiosarcoma is usually treated with conventional anti-tumor agents, which can control disease evolution, but do not clear the latent KSHV episome that binds to cellular DNA...

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Bibliografiske detaljer
Udgivet i:J Antibiot (Tokyo)
Main Authors: Angius, Fabrizio, Piras, Enrica, Uda, Sabrina, Madeddu, Clelia, Serpe, Roberto, Bigi, Rachele, Chen, Wuguo, Dittmer, Dirk P., Pompei, Raffaello, Ingianni, Angela
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002838/
https://ncbi.nlm.nih.gov/pubmed/28611469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2017.67
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