Antimicrobial sulfonamides clear latent Kaposi Sarcoma Herpesvirus infection and impair MDM2-p53 complex formation

Kaposi Sarcoma Herpesvirus (KSHV), also known as Human Herpesvirus 8, is the causative agent of Kaposi sarcoma; this malignant angiosarcoma is usually treated with conventional anti-tumor agents, which can control disease evolution, but do not clear the latent KSHV episome that binds to cellular DNA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Antibiot (Tokyo)
Prif Awduron: Angius, Fabrizio, Piras, Enrica, Uda, Sabrina, Madeddu, Clelia, Serpe, Roberto, Bigi, Rachele, Chen, Wuguo, Dittmer, Dirk P., Pompei, Raffaello, Ingianni, Angela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002838/
https://ncbi.nlm.nih.gov/pubmed/28611469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2017.67
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg