Desymmetrization of meso-Dibromocycloalkenes through Copper(I)-Catalyzed Asymmetric Allylic Substitution with Organolithium Reagents

[Image: see text] The highly regio- and enantioselective (up to >99:1 dr, up to 99:1 er) desymmetrization of meso-1,4-dibromocycloalk-2-enes using asymmetric allylic substitution with organolithium reagents to afford enantioenriched bromocycloalkenes (ring size of 5 to 7) has been achieved. The c...

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Publicat a:J Am Chem Soc
Autors principals: Goh, Shermin S., Guduguntla, Sureshbabu, Kikuchi, Takashi, Lutz, Martin, Otten, Edwin, Fujita, Makoto, Feringa, Ben L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002767/
https://ncbi.nlm.nih.gov/pubmed/29790736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02992
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