Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production

RIG-I is a major cytoplasmic sensor of viral pathogen-associated molecular pattern (PAMP) RNA and induces type I interferon (IFN) production upon viral infection. A double-stranded RNA (dsRNA)-binding protein, PACT, plays an important role in potentiating RIG-I function. We have shown previously tha...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Shao, Junjie, Huang, Qinfeng, Liu, Xiaoying, Di, Da, Liang, Yuying, Ly, Hinh
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002705/
https://ncbi.nlm.nih.gov/pubmed/29669840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00482-18
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