In Vitro and In Vivo Characterizations of Pichinde Viral Nucleoprotein Exoribonuclease Functions

Arenaviruses cause severe hemorrhagic fever diseases in humans, and there are limited preventative and therapeutic measures against these diseases. Previous structural and functional analyses of arenavirus nucleoproteins (NPs) revealed a conserved DEDDH exoribonuclease (RNase) domain that is importa...

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Bibliographic Details
Published in:J Virol
Main Authors: Huang, Qinfeng, Shao, Junjie, Lan, Shuiyun, Zhou, Yanqin, Xing, Junji, Dong, Changjiang, Liang, Yuying, Ly, Hinh
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468471/
https://ncbi.nlm.nih.gov/pubmed/25878103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00009-15
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