Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

Loss of secretory IgA is common in the small airways of patients with chronic obstructive pulmonary disease and may contribute to disease pathogenesis. Using mice that lack secretory IgA in the airways due to genetic deficiency of polymeric Ig receptor (pIgR(−/−) mice), we investigated the role of n...

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Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Richmond, Bradley W., Du, Rui-Hong, Han, Wei, Benjamin, John T., van der Meer, Riet, Gleaves, Linda, Guo, Marshall, McKissack, Austin, Zhang, Yongqin, Cheng, Dong-Sheng, Polosukhin, Vasiliy V., Blackwell, Timothy S.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002662/
https://ncbi.nlm.nih.gov/pubmed/29314863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0329OC
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