Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

Loss of secretory IgA is common in the small airways of patients with chronic obstructive pulmonary disease and may contribute to disease pathogenesis. Using mice that lack secretory IgA in the airways due to genetic deficiency of polymeric Ig receptor (pIgR(−/−) mice), we investigated the role of n...

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Bibliografiske detaljer
Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Richmond, Bradley W., Du, Rui-Hong, Han, Wei, Benjamin, John T., van der Meer, Riet, Gleaves, Linda, Guo, Marshall, McKissack, Austin, Zhang, Yongqin, Cheng, Dong-Sheng, Polosukhin, Vasiliy V., Blackwell, Timothy S.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002662/
https://ncbi.nlm.nih.gov/pubmed/29314863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0329OC
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