Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl

PURPOSE: The usefulness of hepatocytes isolated from a liver-humanized mouse (PXB-cells) as a model in vitro system for the prediction of the in vivo metabolism of new drugs of abuse was evaluated. METHODS: For the drug metabolism study, fentanyl, a powerful synthetic opioid, and acetylfentanyl, an...

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Pubblicato in:Forensic Toxicol
Autori principali: Kanamori, Tatsuyuki, Togawa-Iwata, Yuko, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Tsujikawa, Kenji, Inoue, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Japan 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002451/
https://ncbi.nlm.nih.gov/pubmed/29963210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11419-018-0425-x
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