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Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl
PURPOSE: The usefulness of hepatocytes isolated from a liver-humanized mouse (PXB-cells) as a model in vitro system for the prediction of the in vivo metabolism of new drugs of abuse was evaluated. METHODS: For the drug metabolism study, fentanyl, a powerful synthetic opioid, and acetylfentanyl, an...
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| 發表在: | Forensic Toxicol |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer Japan
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6002451/ https://ncbi.nlm.nih.gov/pubmed/29963210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11419-018-0425-x |
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