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Correlations between metabolism and structural elements of the alicyclic fentanyl analogs cyclopropyl fentanyl, cyclobutyl fentanyl, cyclopentyl fentanyl, cyclohexyl fentanyl and 2,2,3,3-tetramethylcyclopropyl fentanyl studied by human hepatocytes and LC-QTOF-MS

Recently, a number of fentanyl analogs have been implicated in overdose deaths in Europe and in the US. So far, little is known of the molecular behavior of the structurally related subgroup; the alicyclic fentanyls. In this study, reference standards of cyclopropyl, cyclobutyl, cyclopentyl, cyclohe...

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Bibliografske podrobnosti
izdano v:Arch Toxicol
Main Authors: Åstrand, Anna, Töreskog, Amanda, Watanabe, Shimpei, Kronstrand, Robert, Gréen, Henrik, Vikingsson, Svante
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342890/
https://ncbi.nlm.nih.gov/pubmed/30361799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2330-9
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