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Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
A recently developed adenine base editor (ABE) efficiently converts A to G and is potentially useful for clinical applications. However, its precision and efficiency in vivo remains to be addressed. Here we achieve A-to-G conversion in vivo at frequencies up to 100% by microinjection of ABE mRNA tog...
Zapisane w:
| Wydane w: | Nat Commun |
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| Główni autorzy: | , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group UK
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6002399/ https://ncbi.nlm.nih.gov/pubmed/29904106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04768-7 |
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