Rac1 muscle knockout exacerbates the detrimental effect of high‐fat diet on insulin‐stimulated muscle glucose uptake independently of Akt

KEY POINTS: The actin cytoskeleton regulating GTPase, Rac1, is a novel player in insulin-stimulated glucose uptake in muscle in vivo. High‐fat diet (HFD) exacerbates muscle insulin resistance in Rac1 muscle knockout (mKO) mice. Muscle Rac1 KO protects against HFD‐induced insulin resistance in fat ti...

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Publicado en:J Physiol
Autores principales: Raun, Steffen H., Ali, Mona, Kjøbsted, Rasmus, Møller, Lisbeth L. V., Federspiel, Morten A., Richter, Erik A., Jensen, Thomas E., Sylow, Lykke
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Endocrine, nutrition and metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002211/
https://ncbi.nlm.nih.gov/pubmed/29749029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275602
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