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Rac1 muscle knockout exacerbates the detrimental effect of high‐fat diet on insulin‐stimulated muscle glucose uptake independently of Akt

KEY POINTS: The actin cytoskeleton regulating GTPase, Rac1, is a novel player in insulin-stimulated glucose uptake in muscle in vivo. High‐fat diet (HFD) exacerbates muscle insulin resistance in Rac1 muscle knockout (mKO) mice. Muscle Rac1 KO protects against HFD‐induced insulin resistance in fat ti...

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Foilsithe in:J Physiol
Main Authors: Raun, Steffen H., Ali, Mona, Kjøbsted, Rasmus, Møller, Lisbeth L. V., Federspiel, Morten A., Richter, Erik A., Jensen, Thomas E., Sylow, Lykke
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2018
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002211/
https://ncbi.nlm.nih.gov/pubmed/29749029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275602
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