Cellular Senescence Biomarker p16(INK4a)+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women

BACKGROUND: Ample evidence implicates cellular senescence as a contributor to frailty and functional decline in rodents, but considerable effort remains to translate these findings to human aging. METHODS: We quantified senescence biomarker p16(INK4a)-expressing cells in thigh adipose tissue obtaine...

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Bibliografske podrobnosti
izdano v:J Gerontol A Biol Sci Med Sci
Main Authors: Justice, Jamie N, Gregory, Heather, Tchkonia, Tamar, LeBrasseur, Nathan K, Kirkland, James L, Kritchevsky, Stephen B, Nicklas, Barbara J
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
The Journal of Gerontology: Medical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001887/
https://ncbi.nlm.nih.gov/pubmed/28658942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glx134
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