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FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis
F-box and WD repeat domain-containing 7 (FBW7) functions as a major tumor suppressor by targeting oncoproteins for degradations. FBW7 has been reported to be one of the most frequently mutated genes in colorectal cancer (CRC). However, its roles and possible mechanisms in the development of CRC are...
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| Publicado no: | Int J Biol Sci |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Ivyspring International Publisher
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6001674/ https://ncbi.nlm.nih.gov/pubmed/29910683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.24505 |
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