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Discontinuation and dose adjustment of metoprolol after metoprolol‐paroxetine/fluoxetine co‐prescription in Dutch elderly

PURPOSE: Co‐prescription of paroxetine/fluoxetine (a strong CYP2D6 inhibitor) in metoprolol (a CYP2D6 substrate) users is common, but data on the clinical consequences of this drug‐drug interaction are limited and inconclusive. Therefore, we assessed the effect of paroxetine/fluoxetine initiation on...

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Detalhes bibliográficos
Publicado no:Pharmacoepidemiol Drug Saf
Main Authors: Bahar, Muh. Akbar, Wang, Yuanyuan, Bos, Jens H.J., Wilffert, Bob, Hak, Eelko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001522/
https://ncbi.nlm.nih.gov/pubmed/29575226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pds.4422
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