Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

Inspired by our previous efforts on the modifications of diarylpyrimidines as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTI) and reported crystallography study, novel diarylnicotinamide derivatives were designed with a “triazole tail” occupying the entrance channel in the NNRTI bindin...

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Publicado no:Eur J Med Chem
Main Authors: Tian, Ye, Liu, Zhaoqiang, Liu, Jinghan, Huang, Boshi, Kang, Dongwei, Zhang, Heng, De Clercq, Erik, Daelemans, Dirk, Pannecouque, Christophe, Lee, Kuo-Hsiung, Chen, Chin-Ho, Zhan, Peng, Liu, Xinyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001364/
https://ncbi.nlm.nih.gov/pubmed/29635166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.03.059
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