Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery

[Image: see text] Based on the detailed analysis of the binding mode of diarylpyrimidines (DAPYs) with HIV-1 RT, we designed several subseries of novel NNRTIs, with the aim to probe biologically relevant chemical space of solvent-exposed tolerant regions in NNRTIs binding pocket (NNIBP). The most po...

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Udgivet i:ACS Med Chem Lett
Main Authors: Kang, Dongwei, Wang, Zhao, Zhang, Heng, Wu, Gaochan, Zhao, Tong, Zhou, Zhongxia, Huo, Zhipeng, Huang, Boshi, Feng, Da, Ding, Xiao, Zhang, Jian, Zuo, Xiaofang, Jing, Lanlan, Luo, Wei, Guma, Samuel, Daelemans, Dirk, Clercq, Erik De, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900328/
https://ncbi.nlm.nih.gov/pubmed/29670703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00054
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