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Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose

BACKGROUND: For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor the diminished concentrations found in tumor niches. We th...

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Bibliografische gegevens
Gepubliceerd in:Biomark Res
Hoofdauteurs: Walker, Kiera, Boyd, Nathaniel H., Anderson, Joshua C., Willey, Christopher D., Hjelmeland, Anita B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001119/
https://ncbi.nlm.nih.gov/pubmed/29946469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-018-0136-9
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