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Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose

BACKGROUND: For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor the diminished concentrations found in tumor niches. We th...

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Detalhes bibliográficos
Publicado no:Biomark Res
Main Authors: Walker, Kiera, Boyd, Nathaniel H., Anderson, Joshua C., Willey, Christopher D., Hjelmeland, Anita B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001119/
https://ncbi.nlm.nih.gov/pubmed/29946469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-018-0136-9
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