Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines

BACKGROUND AND PURPOSE: Glioblastoma multiforme (GBM) represents the most common and deadly primary brain malignancy, particularly due to temozolomide (TMZ) and radiation (RT) resistance. To better understand resistance mechanisms, we examined global kinase activity (kinomic profiling) in both treat...

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Autors principals: Anderson, Joshua C., Duarte, Christine W., Welaya, Karim, Rohrbach, Timothy D., Bredel, Markus, Yang, Eddy S., Choradia, Nirmal, Thottassery, Jaideep V., Gillespie, G. Yancey, Bonner, James A., Willey, Christopher D.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119546/
https://ncbi.nlm.nih.gov/pubmed/24813092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2014.04.010
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