Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines

BACKGROUND AND PURPOSE: Glioblastoma multiforme (GBM) represents the most common and deadly primary brain malignancy, particularly due to temozolomide (TMZ) and radiation (RT) resistance. To better understand resistance mechanisms, we examined global kinase activity (kinomic profiling) in both treat...

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Detalhes bibliográficos
Main Authors: Anderson, Joshua C., Duarte, Christine W., Welaya, Karim, Rohrbach, Timothy D., Bredel, Markus, Yang, Eddy S., Choradia, Nirmal, Thottassery, Jaideep V., Gillespie, G. Yancey, Bonner, James A., Willey, Christopher D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119546/
https://ncbi.nlm.nih.gov/pubmed/24813092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2014.04.010
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