Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines

BACKGROUND AND PURPOSE: Glioblastoma multiforme (GBM) represents the most common and deadly primary brain malignancy, particularly due to temozolomide (TMZ) and radiation (RT) resistance. To better understand resistance mechanisms, we examined global kinase activity (kinomic profiling) in both treat...

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Bibliografiske detaljer
Main Authors: Anderson, Joshua C., Duarte, Christine W., Welaya, Karim, Rohrbach, Timothy D., Bredel, Markus, Yang, Eddy S., Choradia, Nirmal, Thottassery, Jaideep V., Gillespie, G. Yancey, Bonner, James A., Willey, Christopher D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119546/
https://ncbi.nlm.nih.gov/pubmed/24813092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2014.04.010
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