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In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1(+) BCP-ALL

Despite the addition of tyrosine kinase inhibitors (TKIs) to the treatment of patients with BCR-ABL1(+) B-cell precursor acute lymphoblastic leukemia (BCR-ABL1(+) BCP-ALL), relapse both with and without BCR-ABL1 mutations is a persistent clinical problem. To identify BCR-ABL1–independent genetic med...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Fiedler, Eleanor R. C., Bhutkar, Arjun, Lawler, Emily, Besada, Rana, Hemann, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998924/
https://ncbi.nlm.nih.gov/pubmed/29853524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017015610
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