Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish

The 11q23 of the mixed lineage leukemia 1 (MLL1) gene plays a crucial role in early embryonic development and hematopoiesis. The MLL-AF9 fusion gene, resulting from chromosomal translocation, often leads to acute myeloid leukemia with poor prognosis. Here, we generated a zebrafish model expressing t...

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Publicado en:Biomed Res Int
Autores principales: Tan, Jiaqi, Zhao, Lei, Wang, Gaoxiang, Li, Tongjuan, Li, Dan, Xu, Qian, Chen, Xing, Shang, Zhen, Wang, Jue, Zhou, Jianfeng
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998191/
https://ncbi.nlm.nih.gov/pubmed/30003105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/6705842
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