A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA

Mitochondrial dysfunction is implicated in many neurodegenerative diseases including Parkinson’s disease (PD). Induced pluripotent stem cells (iPSCs) provide a unique cell model for studying neurological diseases. We have established a high-content assay that can simultaneously measure mitochondrial...

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發表在:Sci Rep
Main Authors: Little, Daniel, Luft, Christin, Mosaku, Olukunbi, Lorvellec, Maëlle, Yao, Zhi, Paillusson, Sébastien, Kriston-Vizi, Janos, Gandhi, Sonia, Abramov, Andrey Y., Ketteler, Robin, Devine, Michael J., Gissen, Paul
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998042/
https://ncbi.nlm.nih.gov/pubmed/29899557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27058-0
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