Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy

The pathological cascade leading from primary storage to neural cell dysfunction and death in metachromatic leukodystrophy (MLD) has been poorly elucidated in human-derived neural cell systems. In the present study, we have modeled the progression of pathological events during the differentiation of...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Frati, Giacomo, Luciani, Marco, Meneghini, Vasco, De Cicco, Silvia, Ståhlman, Marcus, Blomqvist, Maria, Grossi, Serena, Filocamo, Mirella, Morena, Francesco, Menegon, Andrea, Martino, Sabata, Gritti, Angela
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997994/
https://ncbi.nlm.nih.gov/pubmed/29899471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0737-0
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