Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy

The pathological cascade leading from primary storage to neural cell dysfunction and death in metachromatic leukodystrophy (MLD) has been poorly elucidated in human-derived neural cell systems. In the present study, we have modeled the progression of pathological events during the differentiation of...

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Publicado en:Cell Death Dis
Main Authors: Frati, Giacomo, Luciani, Marco, Meneghini, Vasco, De Cicco, Silvia, Ståhlman, Marcus, Blomqvist, Maria, Grossi, Serena, Filocamo, Mirella, Morena, Francesco, Menegon, Andrea, Martino, Sabata, Gritti, Angela
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997994/
https://ncbi.nlm.nih.gov/pubmed/29899471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0737-0
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