Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the serum of rheumatoid arthritis and systemic lupus erythematosus (SLE) patients reflects severity of the...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Bartsch, Yannic C., Rahmöller, Johann, Mertes, Maria M. M., Eiglmeier, Susanne, Lorenz, Felix K. M., Stoehr, Alexander D., Braumann, Dominique, Lorenz, Alexandra K., Winkler, André, Lilienthal, Gina-Maria, Petry, Janina, Hobusch, Juliane, Steinhaus, Moritz, Hess, Constanze, Holecska, Vivien, Schoen, Carolin T., Oefner, Carolin M., Leliavski, Alexei, Blanchard, Véronique, Ehlers, Marc
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997785/
https://ncbi.nlm.nih.gov/pubmed/29928274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01183
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