Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs. This interaction is dependent on antigen-dependent hex...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lilienthal, Gina-Maria, Rahmöller, Johann, Petry, Janina, Bartsch, Yannic C., Leliavski, Alexei, Ehlers, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954034/
https://ncbi.nlm.nih.gov/pubmed/29867943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00958
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