Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs. This interaction is dependent on antigen-dependent hex...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Lilienthal, Gina-Maria, Rahmöller, Johann, Petry, Janina, Bartsch, Yannic C., Leliavski, Alexei, Ehlers, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954034/
https://ncbi.nlm.nih.gov/pubmed/29867943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00958
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