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A single cell Wnt signaling niche maintains stemness of alveolar type 2 cells

Lung alveoli are lined by squamous alveolar epithelial type 1 (AT1) epithelial cells that facilitate gas exchange, and neighboring AT2 cells that synthesize and secrete surfactant. Alveoli are maintained by intermittent activation of rare ‘bifunctional’ AT2 cells that retain surfactant biosynthesis...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Nabhan, Ahmad, Brownfield, Douglas G., Krasnow, Mark A., Desai, Tushar J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997265/
https://ncbi.nlm.nih.gov/pubmed/29420258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam6603
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