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Evaluation of the Pharmacokinetics and Safety of a Single Oral Dose of Fasiglifam in Subjects with Mild or Moderate Hepatic Impairment

BACKGROUND AND AIMS: Fasiglifam, a potent, selective novel agonist of G protein-coupled receptor 40, stimulates insulin secretion at elevated blood glucose levels in a glucose-dependent manner. This study evaluated the potential effect of hepatic impairment on the pharmacokinetics and safety of a si...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drugs R D
Main Authors: Marcinak, John, Vakilynejad, Majid, Kogame, Akifumi, Tagawa, Yoshihiko
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995786/
https://ncbi.nlm.nih.gov/pubmed/29488154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-018-0229-9
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