A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor

Epithelial cell-adhesion molecule (EpCAM) is a transmembrane protein that regulates cell cycle progression and differentiation and is overexpressed in many carcinomas. The EpCAM-induced mitogenic cascade is activated via regulated intramembrane proteolysis (RIP) of EpCAM by ADAM and γ-secretases, ge...

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Vydáno v:J Biol Chem
Hlavní autoři: Tretter, Jana Ylva, Schorpp, Kenji, Luxenburger, Elke, Trambauer, Johannes, Steiner, Harald, Hadian, Kamyar, Gires, Olivier, Niessing, Dierk
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995519/
https://ncbi.nlm.nih.gov/pubmed/29700109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002776
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