Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in diastole. This study aimed to develop a high throug...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Liss, Martin, Radke, Michael H., Eckhard, Jamina, Neuenschwander, Martin, Dauksaite, Vita, von Kries, Jens-Peter, Gotthardt, Michael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995442/
https://ncbi.nlm.nih.gov/pubmed/29889873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198492
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