Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in diastole. This study aimed to develop a high throug...

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Foilsithe in:PLoS One
Main Authors: Liss, Martin, Radke, Michael H., Eckhard, Jamina, Neuenschwander, Martin, Dauksaite, Vita, von Kries, Jens-Peter, Gotthardt, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2018
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995442/
https://ncbi.nlm.nih.gov/pubmed/29889873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198492
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