RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in dilated cardiomyopathy (DCM), a major cause of chronic heart failure, presumably through altering cardiac RNA splicing. Here, we combined transcriptome-wide crosslinking immunoprecipitation (CLIP-seq), RNA-seq, and...

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Autori principali: Maatz, Henrike, Jens, Marvin, Liss, Martin, Schafer, Sebastian, Heinig, Matthias, Kirchner, Marieluise, Adami, Eleonora, Rintisch, Carola, Dauksaite, Vita, Radke, Michael H., Selbach, Matthias, Barton, Paul J.R., Cook, Stuart A., Rajewsky, Nikolaus, Gotthardt, Michael, Landthaler, Markus, Hubner, Norbert
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109538/
https://ncbi.nlm.nih.gov/pubmed/24960161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74523
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