Role of p27(Kip1) as a transcriptional regulator

The protein p27(Kip1) is a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors. It interacts with both the catalytic and the regulatory subunit (cyclin) and introduces a region into the catalytic cleave of the Cdk inducing its inactivation. Its inhibitory capacity can be modulat...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Bachs, Oriol, Gallastegui, Edurne, Orlando, Serena, Bigas, Anna, Morante-Redolat, José Manuel, Serratosa, Joan, Fariñas, Isabel, Aligué, Rosa, Pujol, Maria Jesús
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995243/
https://ncbi.nlm.nih.gov/pubmed/29899857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25447
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