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p27(Kip1) and p21(Cip1) collaborate in the regulation of transcription by recruiting cyclin–Cdk complexes on the promoters of target genes

Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G(1) phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk inhibit...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Orlando, Serena, Gallastegui, Edurne, Besson, Arnaud, Abril, Gabriel, Aligué, Rosa, Pujol, Maria Jesus, Bachs, Oriol
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538812/
https://ncbi.nlm.nih.gov/pubmed/26071952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv593
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