Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger–containing 1 (UHRF1) for anti-cancer drug development

Ubiquitin-like containing PHD Ring Finger 1 (UHRF1) is a multi-domain protein with a methyl-DNA binding SRA (SET and RING-associated) domain, required for maintenance DNA methylation mediated by DNMT1. Primarily expressed in proliferating cells, UHRF1 is a cell-cycle regulated protein that is requir...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Patnaik, Debasis, Estève, Pierre-Olivier, Pradhan, Sriharsa
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995235/
https://ncbi.nlm.nih.gov/pubmed/29899856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25425
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