The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence

As senescence develops, cells sequentially acquire diverse senescent phenotypes along with simultaneous multistage gene reprogramming. It remains unclear what acts as the key regulator of the collective changes in gene expression at initiation of senescent reprogramming. Here we analyzed time series...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jung, Hyun-Jung, Byun, Hae-Ok, Jee, Byul A., Min, Seongki, Jeoun, Un-woo, Lee, Young-Kyoung, Seo, Yonghak, Woo, Hyun Goo, Yoon, Gyesoon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339756/
https://ncbi.nlm.nih.gov/pubmed/28100769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750539
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