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An MG53-IRS1-interaction disruptor ameliorates insulin resistance
Mitsugumin 53 (MG53) is an E3 ligase that induces insulin receptor substrate-1 (IRS-1) ubiquitination and degradation in skeletal muscle. We previously demonstrated that the pharmaceutical disruption of the MG53-IRS-1 interaction improves insulin sensitivity by abrogating IRS-1 ubiquitination and in...
Shranjeno v:
| izdano v: | Exp Mol Med |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5994830/ https://ncbi.nlm.nih.gov/pubmed/29884820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-018-0099-9 |
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