MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signaling

Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is a ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme UBE2H. Molecular manipulations that disrupt the E3 ligase func...

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Autores principales: Yi, Jae-Sung, Park, Jun Sub, Ham, Young-Mi, Nguyen, Nga, Lee, Na-Rae, Hong, Jin, Kim, Bong-Woo, Lee, Hyun, Lee, Chang-Seok, Jeong, Byung-Cheon, Song, Hyun Kyu, Cho, Hana, Kim, Yoon Ki, Lee, Jae-Seon, Park, Kyong-Soo, Shin, Hakseob, Choi, Inho, Lee, Seung Hee, Park, Woo Jin, Park, Shi-Young, Choi, Cheol Soo, Lin, Peihui, Karunasiri, Malith, Tan, Tao, Duann, Pu, Zhu, Hua, Ma, Jianjie, Ko, Young-Gyu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941707/
https://ncbi.nlm.nih.gov/pubmed/23965929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3354
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