Mitochondrial Complex I Deficiency Enhances Skeletal Myogenesis but Impairs Insulin Signaling through SIRT1 Inactivation

To address whether mitochondrial biogenesis is essential for skeletal myogenesis, C2C12 myogenesis was investigated after knockdown of NADH dehydrogenase (ubiquintone) flavoprotein 1 (NDUFV1), which is an oxidative phosphorylation complex I subunit that is the first subunit to accept electrons from...

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Главные авторы: Hong, Jin, Kim, Bong-Woo, Choo, Hyo-Jung, Park, Jung-Jin, Yi, Jae-Sung, Yu, Dong-Min, Lee, Hyun, Yoon, Gye-Soon, Lee, Jae-Seon, Ko, Young-Gyu
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106319/
https://ncbi.nlm.nih.gov/pubmed/24895128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.560078
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