MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle

Mitsugumin 53 (MG53) is an E3 ligase that interacts with and ubiquitinates insulin receptor substrate-1 (IRS-1) in skeletal muscle; thus, an MG53-IRS-1 interaction disruptor (MID), which potentially sensitizes insulin signaling with an elevated level of IRS-1 in skeletal muscle, is an excellent cand...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lee, Hyun, Park, Jung-Jin, Nguyen, Nga, Park, Jun Sub, Hong, Jin, Kim, Seung-Hyeob, Song, Woon Young, Kim, Hak Joong, Choi, Kwangman, Cho, Sungchan, Lee, Jae-Seon, Kim, Bong-Woo, Ko, Young-Gyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207173/
https://ncbi.nlm.nih.gov/pubmed/27810898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754424
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