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MERIT reveals the impact of genomic context on sequencing error rate in ultra-deep applications

BACKGROUND: Rapid progress in high-throughput sequencing (HTS) and the development of novel library preparation methods have improved the sensitivity of detecting mutations in heterogeneous samples, specifically in high-depth (> 500×) clinical applications. However, HTS methods are bounded by the...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Hadigol, Mohammad, Khiabanian, Hossein
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994075/
https://ncbi.nlm.nih.gov/pubmed/29884116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2223-1
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