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MERIT reveals the impact of genomic context on sequencing error rate in ultra-deep applications
BACKGROUND: Rapid progress in high-throughput sequencing (HTS) and the development of novel library preparation methods have improved the sensitivity of detecting mutations in heterogeneous samples, specifically in high-depth (> 500×) clinical applications. However, HTS methods are bounded by the...
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Publicado no: | BMC Bioinformatics |
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Main Authors: | , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5994075/ https://ncbi.nlm.nih.gov/pubmed/29884116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2223-1 |
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