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Effect of the 5-HT(4) receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract

OBJECTIVE: Tegaserod is a 5-hydroxytryptamine type 4 (5-HT(4)) receptor agonist, formerly used in treating constipation predominant irritable bowel syndrome, which desensitizes 5-HT(4) receptors in rat oesophagus and colon in vitro. Desensitization of 5-HT(4) receptors is regulated by G-protein coup...

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Bibliografische gegevens
Gepubliceerd in:BMC Res Notes
Hoofdauteurs: Nedi, Teshome, White, Paul J., Coupar, Ian M., Irving, Helen R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994065/
https://ncbi.nlm.nih.gov/pubmed/29884229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13104-018-3495-2
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