Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment

We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising. We developed a distinctly different approach using...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Arai, Yasuyuki, Choi, Uimook, Corsino, Cristina I., Koontz, Sherry M., Tajima, Masaki, Sweeney, Colin L., Black, Mary A., Feldman, Steven A., Dinauer, Mary C., Malech, Harry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993968/
https://ncbi.nlm.nih.gov/pubmed/29622475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.03.003
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