SIRT1 regulates nuclear number and domain size in skeletal muscle fibers

Skeletal muscle fibers are giant multinucleated cells wherein individual nuclei govern the protein synthesis in a finite volume of cytoplasm; this is termed the myonuclear domain (MND). The factors that control MND size remain to be defined. In the present study, we studied the contribution of the N...

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Bibliographic Details
Published in:J Cell Physiol
Main Authors: Ross, Jacob A., Levy, Yotam, Svensson, Kristoffer, Philp, Andrew, Schenk, Simon, Ochala, Julien
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Original Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993587/
https://ncbi.nlm.nih.gov/pubmed/29574748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26542
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