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Latch and trigger role for R445 in DAT transport explains molecular basis of DTDS

A recent study reports on five different mutations as sources of Dopamine transporter (DAT) deficiency syndrome (DTDS). One of these mutations, R445C, is believed to be located on the intracellular side of DAT distant to the primary (S1) or secondary (S2) sites to which substrate binding is understo...

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Bibliografski detalji
Izdano u:Bioorg Med Chem Lett
Glavni autori: Reith, Maarten E.A., Jones, Kymry T., Zhen, Juan, Topiol, Sid
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993566/
https://ncbi.nlm.nih.gov/pubmed/29258773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.12.016
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