Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses. To probe the molecular basis of US28’s unique ligand cross-reactivity, we deep-sequenced CX3CL1 chemokin...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Miles, Timothy F, Spiess, Katja, Jude, Kevin M, Tsutsumi, Naotaka, Burg, John S, Ingram, Jessica R, Waghray, Deepa, Hjorto, Gertrud M, Larsen, Olav, Ploegh, Hidde L, Rosenkilde, Mette M, Garcia, K Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993540/
https://ncbi.nlm.nih.gov/pubmed/29882741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35850
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