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Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1
Chemokines interact with their G protein-coupled receptors (GPCRs) through a two-step, two-site mechanism and, through this interaction, mediate a wide array of homeostatic and immune response mechanisms. Upon initial recognition of the chemokine by the receptor, the N-terminus of the chemokine inse...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6733756/ https://ncbi.nlm.nih.gov/pubmed/31481523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat4128 |
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